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GHRP-2 is a synthetic growth hormone secretagogue that binds to the ghrelin/growth hormone secretagogue receptor. It has been shown in research trials to improve muscle growth, regulate the immune system, and improve sleep cycles. GHRP-2 research has shown that it has oral bio-activity.
GHRP-2 is typically administered via subcutaneous injection once or multiple times daily, depending on the desired outcome — such as increasing natural growth hormone (GH) levels, enhancing recovery, or promoting lean body mass.
A common starting dose is 100 mcg (0.05 ml) once daily, ideally taken before bed. As tolerance and response are assessed, this can be increased to 200 mcg (0.1 ml) per injection. Many protocols include two or three daily doses for more robust GH stimulation.
A progressive protocol may follow this structure:
Week 1–2: 100 mcg (0.05 ml) once daily at bedtime
Week 3–4: Increase to 200 mcg (0.1 ml) once or twice daily
Week 5 and beyond: 200–300 mcg (0.1–0.15 ml), up to three times daily, spaced 3–4 hours apart (e.g., morning, afternoon, bedtime)
Injections are administered subcutaneously into the abdominal area or thigh. It’s important to inject on an empty stomach, as carbohydrates and fats can suppress GH release post-injection.
Each 10ml vial provides 20 mg of GHRP-2, allowing for:
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that stimulates the pituitary gland to increase endogenous GH secretion. It acts on ghrelin (GHSR-1a) receptors, making it both a GH secretagogue and an appetite modulator.
Compared to GHRP-6, GHRP-2 is known for stronger GH release with less appetite stimulation, making it better suited for lean mass protocols and fat loss phases. It has been studied for its potential in treating GH deficiency, improving lean body composition, and supporting recovery after injury or surgery.
GHRP-2 works by stimulating the GHSR-1a (ghrelin) receptor, which leads to direct pituitary release of growth hormone. This mechanism bypasses the GHRH axis and is highly effective even in cases of impaired hypothalamic signaling.
Key actions include:
Rapid and dose-dependent GH secretion
Enhanced IGF-1 production via hepatic stimulation
Improved muscle protein synthesis and tissue regeneration
Support for lipid metabolism and body recomposition
Mild appetite enhancement, depending on dosage
It synergizes well with GHRH analogs like CJC-1295 for compounded GH release.
GHRP-2 may have synergistic effects when combined with:
GHRH analogs (e.g., CJC-1295)
BPC-157 or TB-500 for recovery enhancement
Other GH secretagogues (e.g., Ipamorelin)
No known negative pharmacologic interactions with common medications have been reported. However, GH stimulation may affect insulin sensitivity slightly in some individuals.
GHRP-2 has not been studied in pregnant or breastfeeding individuals and is not recommended during these periods. Its hormonal activity could theoretically influence fetal development or lactation.
While GHRP-2 does stimulate GH release, it is not approved for pediatric use. Any use in children must be closely supervised by a qualified pediatric endocrinologist under strict monitoring.
GHRP-2 is currently classified as an investigational compound and is not approved by the FDA for therapeutic use. It is used in compounding pharmacies and clinical research settings but has not been approved for treating growth hormone deficiency or other medical conditions.
