CJC-1295, Ipamorelin (20mg) (DAC) (Blend)
Original price was: $100.00.$92.40Current price is: $92.40.
CJC-1295 causes the natural release of GH, but it does so by naturally stimulating the growth hormone releasing hormone receptor.
Ipamorelin is one of the most selective growth hormone (GH) secretagogues known and a potent agonist of the ghrelin/growth hormone secretagogue receptor. It has been heavily researched in a number of settings and is known to, improve bone health, boost muscle repair and development, stimulate insulin release from the pancreas, and improve bowel motility and gastric function.
CJC-1295 when combined with Ipamorelin has been shown to exhibit synergistic effects when researched together.
Contents of the Package
- 1 x 10ml sterile multi-dose vial
- Each ml contains:
- CJC-1295 with DAC: 1 mg
- Ipamorelin: 1 mg
- Clear injectable solution reconstituted in bacteriostatic saline
- Packaged in pharmaceutical-grade vial with tamper-evident seal
- For subcutaneous injection only
About CJC-1295 DAC, Ipamorelin
This combination of CJC-1295 with DAC and Ipamorelin offers a potent, balanced approach to enhancing endogenous growth hormone (GH) and IGF-1 production. While CJC-1295 (a GHRH analog) increases GH pulse amplitude and half-life, Ipamorelin (a GHRP) increases pulse frequency and intensity. Together, they work synergistically to mimic the body’s natural growth hormone pulsatility without disrupting feedback loops or causing excessive side effects.
This blend is commonly used to support:
- Muscle recovery and lean mass development
- Fat loss and metabolic enhancement
- Anti-aging and sleep quality
- Tissue repair, collagen synthesis, and joint health
Mechanism of Action
This combination works via dual stimulation of the growth hormone axis:
- CJC-1295 with DAC binds to GHRH receptors, stimulating the anterior pituitary to release GH in prolonged pulses. DAC technology extends the half-life to ~8–10 days by binding to albumin.
- Ipamorelin binds to the ghrelin receptor (GHSR-1a), triggering rapid GH release with minimal impact on cortisol or prolactin levels.
Together, they:
- Enhance both amplitude and frequency of GH pulses
- Stimulate hepatic IGF-1 production
- Promote anabolism, cellular regeneration, and fat metabolism
- Support neuroprotective and cardiovascular health through GH/IGF-1 modulation
Adverse Reactions
This blend is typically well tolerated due to the clean profiles of both peptides.
Possible side effects may include:
- Temporary water retention or bloating
- Mild flushing or tingling after injection
- Increased hunger (due to Ipamorelin's ghrelin mimetic activity)
- Transient fatigue or drowsiness
- Injection site irritation
- Rare: lightheadedness or slight increase in blood glucose
These effects are generally dose-dependent and resolve with proper cycling or reduction in frequency.
Benefits
Potential Benefits:
- Increased lean muscle mass and fat metabolism
- Improved sleep quality and recovery
- Enhanced collagen synthesis for skin, joints, and connective tissue
- Better mood, cognitive function, and energy levels
- Anti-aging support through elevated IGF-1
Side Effects
⚠️ Possible Side Effects:
- Mild water retention
- Slight flushing, fatigue, or tingling
- Increased hunger (from Ipamorelin)
- Rare: nausea, headache, or short-term dizziness
These effects are typically mild, transient, and reduce with lower or alternate-day dosing.
Contraindications & Precautions
- Not recommended for individuals with active cancers or tumors (due to GH/IGF-1 stimulation)
- Caution in patients with uncontrolled diabetes, as GH may impact insulin sensitivity
- Avoid use in individuals with pituitary adenomas or acromegaly
- Use with caution in those with untreated thyroid or adrenal disorders
Regular monitoring of IGF-1 levels, fasting glucose, and blood pressure is recommended during extended use.
Drug Interactions
- No direct drug-drug interactions have been reported
- May be synergistic with:
- BPC-157 or TB-500 (recovery support)
- L-Carnitine (fat metabolism)
- MK-677 (oral GH secretagogue)
Avoid taking with insulin or IGF-1 boosting agents without medical supervision.
Pregnancy & Breastfeeding
This peptide combination is not recommended for use during pregnancy or lactation. Due to its hormonal effects and lack of safety data in these populations, it should be avoided entirely during these periods.
Children
While GH secretagogues may be used in clinically diagnosed GH deficiency, this blend is not approved for pediatric use and should only be considered under the care of a pediatric endocrinologist. Off-label use in children is not recommended.
FDA approval
- CJC-1295 and Ipamorelin are not FDA-approved for therapeutic use
- Both are classified as investigational compounds and are available through compounding pharmacies for clinician-directed protocols
- Not to be confused with recombinant GH, which is FDA-approved for GH deficiency
References
- Teichman SL, et al. (2006). “Pharmacokinetics of CJC-1295, a long-acting GHRH analog.” J Clin Endocrinol Metab.
- Smith RG, et al. (2005). “Selective GHSs like Ipamorelin and their GH-stimulating effects.” Endocrine Reviews.
- Nass R, et al. (2008). “Ipamorelin: a potent, well-tolerated GH secretagogue.” Growth Horm IGF Res.
- Liu NA, et al. (2021). “Use of GHRH and GHRP combinations in metabolic health.” Trends in Endocrinology.
- Meinhardt U, et al. (2010). “Endocrine response to GHRP + GHRH combinations.” Hormone Research in Pediatrics.